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Flow Chemistry Reactions


This page includes a list of flow chemistry application notes and reactions using Syrris' flow chemistry systems. Syrris' innovative microreactor based systems include the modular Asia, Africa and FRX product ranges.





1 – Acid fluoride synthesis

This paper describes a safe and effective method for the synthesis of acid fluorides by fluorination of carboxylic acids using DAST (diethylaminosulfur trifluoride) nucleophilic fluorinating reagent..

Acid fluoride synthesis

Authors
Tomas Gustafsson, Ryan Gilmour,
Peter H. Seeberger
(ETH Zurich)

System
Syrris FRX

See Abstract &

Link to Paper

2 – Fluorination of benzylic and secondary alcohols

This paper describes a safe and effective method for the fluorination of benzylic and secondary alcohols using DAST (diethylaminosulfur trifluoride) nucleophilic fluorinating reagent.

 Fluorination of benzylic and secondary alcohols

Authors
Tomas Gustafsson, Ryan Gilmour,
Peter H. Seeberger
(ETH Zurich)

System
Syrris FRX

See Abstract &
Link to Paper

3 – Hantzsch synthesis of pyrrole-3-carboxylic acid

This paper describes experimental conditions for a fast Hantzsch reaction in continuous flow microreactors with in-situ hydrolysis to form substituted pyrrole-3-carboxylic acid. The process is applicable to a wide range of substrates with good to moderate yields..

Hantzsch synthesis of pyrrole-3-carboxylic acid

Authors
Ananda Herath, Nicholas D. P. Cosford
(Burnham Institute)

System

Syrris Africa

See Abstract &
Link to Paper

4 – Hantzsch synthesis of pyrrole-3-carboxylic ester

This paper describes experimental conditions for a quick Hantzsch reaction in continuous flow microreactor for the synthesis of substituted pyrrole-3-carboxylic ester. The process is applicable to a wide range of substrates with good to moderate yields.

Authors
Ananda Herath, Nicholas D. P. Cosford
(Burnham Institute)

System

Syrris Africa

See Abstract &
Link to Paper

5 – Triazole synthesis by [3+2]-cycloaddition

This paper describes optimized reaction conditions for a [3+2]-cycloaddition for the continuous multi-gram synthesis of 5-Amino-1-(2-phenylthioethy-1-yl)-1,2,3-triazole-4-carboxamide. The optimization work carried on the [3+2]-cycloaddition is also described.

5 – Triazole synthesis by [3+2]-cycloaddition

Authors
Rob Tinder, Roger Farr, Richard Heid,
Ralph Zhao, Randy S. Rarig, Jr and

Thomas Storz (Wyeth)

System
Syrris Africa

See Abstract &
Link to Paper

6 – Oxadiazole synthesis

This paper describes a general method for the synthesis of bis-substituted 1,2,4-oxadiazoles in one continuous flow sequence. 1,2,4-oxadiazoles are obtained in moderate yields with a variety of substrates.

6 – Oxadiazole synthesis

Authors
Daniel Grant, Russell Dahl, and
Nicholas D. P. Cosford
(Burnham Institute)

System
Syrris Africa

See Abstract &
Link to Paper

7 – Bohlmann-Rahtz pyridine synthesis;

This paper describes practical conditions for Bohlmann–Rahtz cyclodehydration of aminodienones into pyridines with excellent conversion rates.

7 – Bohlmann-Rahtz pyridine synthesis

Authors
Mark C. Bagley, Vincenzo Fusillo,
Robert L. Jenkins, M. Caterina Lubinu
and Christopher Mason
(Cardiff University)

System
Syrris Africa

See Abstract &
Link to Paper

8 – Imidazo[1,2-a]pyridine Heterocycles synthesis

This paper describes a protocol for imidazo[1,2-a]pyridine-2-carboxylic acids synthesis directly from condensation of substituted 2-aminopyridines and bromopyruvic acid. The recipe is applicable to a wide range of aminopyridines and can be telescoped with an amide formation to obtain Imidazo[1,2-a]pyridine-2-carboxamides in one continuous process.

8 – Imidazo[1,2-a]pyridine Heterocycles synthesis

Authors
Ananda Herath, Russell Dahl,
and Nicholas D. P. Cosford
(Burnham Institute)

System
Syrris Africa

See Abstract &
Link to Paper

9 – Amide bond formation

A continuous liquid-liquid method for formation of an amide bond is described. The process uses HOBt as activating group and is applied to a range of heterocyclic carboxylic acids and primary amines.

9 – Amide bond formation

Authors
Ananda Herath, Russell Dahl,
and Nicholas D. P. Cosford
(Burnham Institute)

System
Syrris Africa

See Abstract &
Link to Paper

10 – Knorr pyrazole synthesis

This paper describes a continuous method for the synthesis of pyrazoles via condensation of 1,3-dicarbonyls and hydrazines.

10 – Knorr pyrazole synthesis

Authors
Jacques Pelleter and Fabrice Renaud

(AstraZeneca)

System
Syrris FRX

See Abstract &
Link to Paper

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