Flow Chemistry Reactions
This page includes a list of flow chemistry application notes and reactions using Syrris' flow chemistry systems. Syrris' innovative microreactor based systems include the modular Asia, Africa and FRX product ranges.
1 – Acid fluoride synthesis
This paper describes a safe and effective method for the synthesis of acid fluorides by fluorination of carboxylic acids using DAST (diethylaminosulfur trifluoride) nucleophilic fluorinating reagent..
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2 – Fluorination of benzylic and secondary alcohols
This paper describes a safe and effective method for the fluorination of benzylic and secondary alcohols using DAST (diethylaminosulfur trifluoride) nucleophilic fluorinating reagent.
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3 – Hantzsch synthesis of pyrrole-3-carboxylic acid
This paper describes experimental conditions for a fast Hantzsch reaction in continuous flow microreactors with in-situ hydrolysis to form substituted pyrrole-3-carboxylic acid. The process is applicable to a wide range of substrates with good to moderate yields..
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System Syrris Africa |
4 – Hantzsch synthesis of pyrrole-3-carboxylic ester
This paper describes experimental conditions for a quick Hantzsch reaction in continuous flow microreactor for the synthesis of substituted pyrrole-3-carboxylic ester. The process is applicable to a wide range of substrates with good to moderate yields.
| Authors Ananda Herath, Nicholas D. P. Cosford (Burnham Institute) |
System Syrris Africa |
5 – Triazole synthesis by [3+2]-cycloaddition
This paper describes optimized reaction conditions for a [3+2]-cycloaddition for the continuous multi-gram synthesis of 5-Amino-1-(2-phenylthioethy-1-yl)-1,2,3-triazole-4-carboxamide. The optimization work carried on the [3+2]-cycloaddition is also described.
![5 – Triazole synthesis by [3+2]-cycloaddition](http://www.megantech.pl/file/5_Triazole_synthesis_by_3_2_cycloaddition_4.png "5 – Triazole synthesis by [3+2]-cycloaddition")
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Authors Thomas Storz (Wyeth) |
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6 – Oxadiazole synthesis
This paper describes a general method for the synthesis of bis-substituted 1,2,4-oxadiazoles in one continuous flow sequence. 1,2,4-oxadiazoles are obtained in moderate yields with a variety of substrates.
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7 – Bohlmann-Rahtz pyridine synthesis;
This paper describes practical conditions for Bohlmann–Rahtz cyclodehydration of aminodienones into pyridines with excellent conversion rates.
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8 – Imidazo[1,2-a]pyridine Heterocycles synthesis
This paper describes a protocol for imidazo[1,2-a]pyridine-2-carboxylic acids synthesis directly from condensation of substituted 2-aminopyridines and bromopyruvic acid. The recipe is applicable to a wide range of aminopyridines and can be telescoped with an amide formation to obtain Imidazo[1,2-a]pyridine-2-carboxamides in one continuous process.
![8 – Imidazo[1,2-a]pyridine Heterocycles synthesis](http://www.megantech.pl/file/8_Imidazo_1_2_a_pyridine_Heterocycles_synthesis_2.png "8 – Imidazo[1,2-a]pyridine Heterocycles synthesis")
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9 – Amide bond formation
A continuous liquid-liquid method for formation of an amide bond is described. The process uses HOBt as activating group and is applied to a range of heterocyclic carboxylic acids and primary amines.
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10 – Knorr pyrazole synthesis
This paper describes a continuous method for the synthesis of pyrazoles via condensation of 1,3-dicarbonyls and hydrazines.
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Authors (AstraZeneca) |
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