Fluorination reactions in microreactors
Chem. Commun., 2008, 3022-3024
Tomas Gustafsson, Ryan Gilmour and Peter H. Seeberger*
Swiss Federal Institute of Technology, Zurich, Laboratorium für Organische Chemie, Switzerland
This paper describes a fast, safe and continuous fluorination protocol using DAST for primary alcohols, carboxylic acids and aldehydes conducted in a Syrris Tube Reactor on a Syrris FRX system.
Abstract: The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale.
To download the paper click here
This paper uses an FRX flow chemistry system. See the products this chemistry was performed on:
- FRX Flow Chemistry Overview
- Syrris Flow Products