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Fluorination reactions in microreactors


Chem. Commun., 2008, 3022-3024
Tomas Gustafsson, Ryan Gilmour and Peter H. Seeberger*
Swiss Federal Institute of Technology, Zurich, Laboratorium für Organische Chemie, Switzerland

This paper describes a fast, safe and continuous fluorination protocol using DAST for primary alcohols, carboxylic acids and aldehydes conducted in a Syrris Tube Reactor on a Syrris FRX system.

Acid fluoride synthesis
FRX

Abstract: The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale.
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This paper uses an FRX flow chemistry system. See the products this chemistry was performed on:

  • FRX Flow Chemistry Overview
  • Syrris Flow Products
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