The VenaT4™ biochip for chemotaxis, transmigration and invasion assays. Compatible with brightfield, phase contrast imaging and fluorescence microscopy.

Features:

• Chemotaxis, transmigration and invasion assays: in-vivo like setting; cells adhere from flow and transmigrate through embedded microporous membrane (2-10 μm pore sizes) into underlying microwell containing chemoattractant.
• Suitable for ECM-matrix, collagen gels, hydrogels, matrigel or similar aqueous gels.
• Cells may also be cultured in the underlying microwell with/without gel.
• Faster than traditional chemotaxis assays due to reduced distance in microchannel format.
• Suitable for whole blood, primary cells, rare cells e.g. where samples are more difficult to retrieve or culture or only small sample volumes available.
• No assembly of the biochip is required unlike many standard perfusion chambers / flow chambers.
• No luer lock connections which increase dead volume. Cellix's biochips have a unique plug & play connection with tubing connections which are autoclaveable and reuseable. Dead volume is at input port ~ 0.1μL.

Applications: Chemotaxis, transmigration and invasion assays using minimal sample volumes (whole blood, cell suspensions, proteins etc.); brightfield, phase contrast and fluorescence microscopy.