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VenaT4 Biochip

VenaT4 Biochip

The VenaT4™ biochip for chemotaxis, transmigration and invasion assays. Compatible with brightfield, phase contrast imaging and fluorescence microscopy.


  • Chemotaxis, transmigration and invasion assays: in-vivo like setting; cells adhere from flow and transmigrate through embedded microporous membrane (2-10 μm pore sizes) into underlying microwell containing chemoattractant.
  • Suitable for ECM-matrix, collagen gels, hydrogels, matrigel or similar aqueous gels.
  • Cells may also be cultured in the underlying microwell with/without gel.
  • Faster than traditional chemotaxis assays due to reduced distance in microchannel format.
  • Suitable for whole blood, primary cells, rare cells e.g. where samples are more difficult to retrieve or culture or only small sample volumes available.
  • No assembly of the biochip is required unlike many standard perfusion chambers / flow chambers.
  • No luer lock connections which increase dead volume. Cellix's biochips have a unique plug & play connection with tubing connections which are autoclaveable and reuseable. Dead volume is at input port ~ 0.1μL.

Applications: Chemotaxis, transmigration and invasion assays using minimal sample volumes (whole blood, cell suspensions, proteins etc.); brightfield, phase contrast and fluorescence microscopy.


Substrate thickness  0.5mm = 500μm
Substrate material  High quality plastic, compatible with brightfield, phase contrast imaging and fluorescence microscopy
Number of channels / microwells per biochip  4
Height of channels  0.1mm = 100μm
Width of channels  0.8mm = 800μm
Length of channels  28mm = 2.8cm
Volume of each channel  2.253μL
Volume of protein required for coating channel  50μL
Volume of gel required for microwell  30μL
Volume of reservoir to hold sample  0.5mL; also possible to connect via tubing to eppendorf if greater sample volume or high shear stress / flow rate assay is being perfor